Apples Worthy iPhone 8 Models May Languish in Xs Shadow

first_imgOne point of controversy is whether the new iPhone models deserve the “8” designation or are just “s” versions of the iPhone 7 in a glass case.”The iPhone 8 reminds me of the fifth Transformers movie — you know it’s new, though you can’t for the life of you figure out how it’s different,” wrote Geoffrey A. Fowler for The Wall Street Journal.”On its face, the 8 looks like an iPhone from 2014,” he added.However, the switch to a glass back with wireless charging and the new processor validate a full number bump, argued Kevin Krewell, principal analyst at Tirias Research.”There are enough changes to the design and functionality so that I would give it a full number increase and not an ‘S’ designator,” he told TechNewsWorld. The 8s are familiar-looking phones that mostly operate the way people expect them to, observed Chris Velazco for Engadget.”They’re conventional, but that doesn’t mean they’re inherently lacking — far from it, in fact,” he wrote.”While I suspect all iPhones will look like the iPhone X soon enough,” Velazco continued, “the 8 and 8 Plus are expertly built, high-performance devices for people who want to ease into Apple’s vision of the future.”Like other reviewers, Velazco preferred the 8 Plus over the 8.”The iPhone 8 Plus shares a powerful foundation with the iPhone 8, but a few features give it a distinct advantage over its little brother,” he wrote. “Its 12-megapixel dual camera is one of the best we’ve used, and its bigger battery means it’ll stick around longer on a charge than the iPhone 8.”Though agreeing with assessments of the 8 Plus’ chops,Cnet Senior Editor Scott Stein advised iPhone shoppers to pause before buying one.”The iPhone 8 Plus is a superlative phone with a spectacular camera, but wait for the upcoming iPhone X before buying: it promises to fold all of the key features of the 8 Plus into a smaller, sexier package,” he wrote. While the X has hogged the spotlight, the 8s are more than mere consolation prizes, maintained Mark Spoonauer in his review for Tom’s Guide.”They pack a ton of improvements, including the fastest processor ever in a phone (seriously, it puts many laptops to shame), better cameras (especially on the iPhone 8 Plus) and wireless charging (yeah, it’s overdue),” he wrote. The 8s aren’t revolutionary like the X. They represent a continuation of what Apple has been doing for some time: tweaking and improving phones each year, noted James Titcomb for The Telegraph.”So the 8 improves enough on the most important aspects of a phone — the display, the camera, performance and reliability — to make me recommend it over the iPhone 7, even if you can pick up the latter for less,” he wrote.Base iPhone 7 models sell for US$579 and the 7 Plus for $669. The 8 sells for $699 and the 8 Plus for $799.Despite pricing differences between the 8s and the X, which sells for $999, Apple may have difficulty selling the lower-priced phones.”Apple will have a challenge convincing users to upgrade to an 8 with the X release date looming,” said David McQueen, research director at ABI Research.”They’re really just an s upgrade,” he told TechNewsWorld.The improvements in the 8s over the previous generation of iPhones and their pricing under $1,000 will be attractive to many Apple users, said Andreas Scherer, managing partner at Salto Partners.However, “the iPhone connoisseurs most certainly will wait a little longer to get their hands on the best phone ever produced by Apple,” he told TechNewsWorld.Those connoisseurs will be a minority — although a substantial minority — of iPhone buyers, however.”The audience for the iPhone X in its first year will be the early adopters and those who can afford to spend the money on it,” said Tim Bajarin, president of Creative Strategies.”That represents about a third of all who will buy the new iPhones.” he told TechNewsWorld. “But two-thirds will opt for the iPhone 8 and 8 Plus, because they’re less expensive, yet have increased power and features over last year’s models.” Especially impressive was the performance of the A11 Bionic processor in the new 8s. “This chip absolutely smokes every Android phone on the planet,” Spoonauer said.”Overall, my pick between the two new iPhones is the iPhone 8 Plus. It gives you a significantly bigger screen than the iPhone 8, longer battery life and more versatile dual cameras for just $100 more,” he pointed out.”The regular iPhone 8 is good,” Spoonauer continued, “but 4.7 inches just doesn’t cut it for me anymore.” Challenged by the X Easing Into the Future Smokes Android iPhone 8 or 7s? Reviews of Apple’s new iPhone 8 and 8 Plus started turning up this week, and for the most part, they’ve been laudatory. However, the reviewers can’t seem to get their minds off the jewel of the Apple universe, the iPhone X.Both the iPhone 8 and 8 Plus are “awesome” and better than last year’s models — but iPhone shoppers who want to be part of the future will save their money and buy an iPhone X later in the year, suggested David Pierce for Wired.”The iPhones 8 check every box a phone has ever checked before, but they feel like the last of something right as Apple and others prepare the first of something else,” he wrote.”When your phone can see you, and see the world,” he continued, “it will change what a phone is, and does, and can be. This fall, Apple’s giving you a choice: get a seat on the best piston airliner ever, or take a chance on jet engines.” John P. Mello Jr. has been an ECT News Network reportersince 2003. His areas of focus include cybersecurity, IT issues, privacy, e-commerce, social media, artificial intelligence, big data and consumer electronics. He has written and edited for numerous publications, including the Boston Business Journal, theBoston Phoenix, Megapixel.Net and GovernmentSecurity News. Email John.last_img read more

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Grants aim to provide better cancer clinical trial access for military veterans

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 9 2018For the fourth year, SWOG Cancer Research Network and its charity, The Hope Foundation for Cancer Research, are giving military veterans better access to cancer clinical trials by providing grant support to U.S. Department of Veterans Affairs medical centers.Under the VA Integration Support Program, medical centers receive a one-time $50,000 grant to help them enroll veterans in trials run by SWOG and other members of the National Cancer Institute’s National Clinical Trials Network (NCTN). This means more veterans get targeted treatments, immunotherapies, and other cutting-edge medicines tested in cancer trials. The NCTN offers dozens of trials for a variety of cancers, including lung, prostate, and colorectal cancers – the most common forms in veterans.VA Integration Support Program award winners for 2018 are: Source:https://www.swog.org/news-events/news/2018/11/08/grants-give-veterans-better-access-trials Central Arkansas Veterans Healthcare System, Little Rock, AR Cincinnati VA Medical Center, Cincinnati, OH Durham VA Medical Center, Durham, NC James J. Peters VA Medical Center, Bronx, NY Orlando VA Medical Center, Orlando, FL Portland VA Health Care System, Portland, OR Richard J. Roudebush VA Medical Center, Indianapolis, IN South Texas Veterans Healthcare System, San Antonio, TX VA Eastern Colorado Health Care System, Denver, CO VA New York Harbor Healthcare System, Manhattan Campus, New York, NY VA Puget Sound Health Care System, Seattle, WA VA Central California Health Care System, Fresno, CA VA Medical Center New Orleans, New Orleans, LA W.G. (Bill) Hefner VA Medical Center, Salisbury, NC Since the SWOG and Hope VA Integration Support Program began in 2015, statistics from NCI’s Clinical Trials Reporting Program show that at these 14 VA centers, 65 veterans have registered to SWOG and other NCI treatment and prevention trials. In 2014, before the program was launched, nine veterans at these 14 centers enrolled on NCI trials. So far in 2018, 23 veterans at these centers have enrolled. That’s more than double the registrations to NCI trials.center_img Dallas VA Medical Center, Dallas, TX George E. Wahlen VA Medical Center, Salt Lake City, UT Giving veterans better access to clinical trials is a priority of the National Cancer Institute, the primary source of funding for SWOG trials. This year, for the first time, the NCI and the VA’s Office of Research and Development provided infrastructure grants to 12 VA medical centers that want to increase participation in NCI trials. The program, the NCI and VA Interagency Group to Accelerate Trails Enrollment (NAVIGATE), is aimed at creating a sustainable national network of sites that offer veterans new cancer treatment options through clinical trials.”Our program, and the NCI program, are complementary,” said Charles D. Blanke, MD, SWOG group chair. “Both have a goal of getting more veterans into trials, and both provide infrastructure support in an effort to meet that goal. It may take years, but I believe that together, SWOG, Hope, and the NCI will make a positive difference for these centers and the veterans they serve.”Offering clinical trials to patients is considered best practice among cancer physicians, because trials offer access to treatments otherwise unavailable. But offering cancer trials is time-intensive and expensive, requiring hospitals to have adequate staff to work with patients before, during, and after their treatment on a trial. Through the VA Integration Support Centers Program, centers use the grants to fund clinical research associates and oncology nurses, the support staff who discuss trials with patients, assist with paperwork, submit tissue samples, record treatment and safety data, and perform other tasks necessary to run safe and effective clinical studies.Related StoriesLiving with advanced breast cancerUsing machine learning algorithm to accurately diagnose breast cancerNew protein target for deadly ovarian cancerIn 2015, 2016, and 2017, SWOG and The Hope Foundation funded these 14 VA centers:last_img read more

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New collaborative partnership in quest of novel antibiotics

first_img Source:https://www.dndi.org/ Reviewed by James Ives, M.Psych. (Editor)Dec 12 2018The Global Antibiotic Research and Development Partnership (GARDP), Eisai Co., Ltd. (“Eisai”) and Takeda Pharmaceutical Company Limited (“Takeda”) have signed an agreement for GARDP to access and screen components of Eisai and Takeda’s chemical libraries. Both libraries will be tested by the Institut Pasteur Korea in the hope of discovering novel compounds with antibacterial activity. This multi-partner agreement supports GARDP’s efforts to tackle serious bacterial infections by developing antibiotics, while endeavouring to ensure their sustainable access.With few antibiotics in development, antimicrobial resistance is a major and rapidly growing global public health concern. Around 700,000 people die of drug-resistant infections every year.1 Serious bacterial infections, and in particular Gram-negative bacterial infections, have been identified by the World Health Organization (WHO) as a global public health priority.The compounds that will be screened have emerged from Eisai and Takeda’s latest medicinal chemistry efforts and have never been screened for antibacterial activity. They will be tested against bacteria identified as a critical priority for research and development of new antibiotics in WHO’s global priority pathogen list.2 Through this screening, GARDP seeks to identify novel compounds suitable for further optimization and development.”GARDP is very excited about this partnership. Not only can partnerships like this accelerate the discovery of new antibiotics, they can also support the pharmaceutical sector in staying engaged in antibiotic R&D,” said Dr Seamus O’Brien, Research and Development Director at GARDP. “Overcoming antibacterial resistance is key to achieve universal health coverage. GARDP’s approach allows us to develop a drug from early exploratory to preclinical and clinical studies all the way to patients.”Related StoriesNew research could help design algae that produces fuels and cleanup chemicalsMathematical model helps quantify metastatic cell behaviorMultifaceted intervention for acute respiratory infection improves antibiotic-prescribing”Eisai strongly identifies with GARDP’s efforts to discover novel antibiotics to treat drug-resistant bacterial infections which have become a threat to human beings and are pleased to provide our compound library for screening. We sincerely hope new medicines will be discovered through this partnership to realize a world in which lives are no longer lost to drug-resistant bacteria,” said Dr Kappei Tsukahara, Senior Group Officer, Head of Human Health Care Data Creation Center, Head of Tsukuba Research Laboratories at Eisai.”Takeda is delighted to contribute to this creative partnership and extend our commitment to promoting the discovery of novel treatments to treat life-threatening antibiotic resistance,” said Dr Ceri Davies, Head of the Neuroscience Drug Discovery Unit at Takeda.Dr. Wangshick Ryu, CEO of the Institut Pasteur Korea said, “We are honoured to collaborate with GARDP on a global project of great importance to find a solution for antibiotic resistance. The world needs global cooperative action to prevent the post-antibiotic era. This work, instigated by GARDP, is an active response to this urgent global demand that connects Institut Pasteur Korea’s resources with the technology of global pharmaceutical companies. We believe that together we can achieve much more.”last_img read more

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Scientists discover puzzle piece that plays key role in development of epilepsies

first_imgReviewed by Kate Anderton, B.Sc. (Editor)Feb 25 2019When an epileptic seizure occurs in the brain, the nerve cells lose their usual pattern and fire in a very fast rhythm. The cause is a complex interplay of various factors. Scientists at the University of Bonn have now discovered the important role of one of the participants: α2δ4 (alpha2delta4). It is a central player between the nerve cells, a puzzle piece that plays a decisive role in the development of epilepsies and is a possible starting point for therapies. The results now appear in The Journal of Neuroscience.During an epileptic seizure, the nerve cells fire simultaneously in a very fast rhythm – like a thunderstorm in the brain. This results in seizures. Due to changes in the brain, such a short seizure can develop into chronic epilepsy in the long term. “The search for new therapies is above all about preventing the gradual development of such severe types of seizures,” says Prof. Dr. Albert J. Becker from the Institute of Neuropathology at the University Hospital Bonn (UKB).When an epileptic seizure occurs, genes and their regulation are also involved. Genes are blueprints of DNA. Transcripts are made of genes during transcription; these then reach different locations in the nerve cells and influence their function. As the scientists at the University of Bonn were able to demonstrate several years ago, the transcription factor Early growth response 1 (Egr1) upregulates the calcium channels in the nerve cells. Calcium can then increasingly flow into the pores of the nerve cell channels. This causes them to start firing in unison – an epileptic seizure begins.Search for epilepsy genes”However, as we have now discovered, the process is much more complex,” says Dr. Karen M. J. van Loo, junior research group leader at the UKB. “There are other factors involved.” Like in a grid search, the scientist and her UKB colleagues Prof. Dr. Dirk Dietrich from Neurosurgery and Prof. Dr. Sandra Blaess from the Institute of Reconstructive Neurobiology used bioinformatic methods to search for additional epilepsy genes involved in the seizures. The researchers then observed the interaction of the epileptic factors in human tissue obtained during surgical removal of epileptic foci from patients’ brains and in mice.Related StoriesMercy Medical Center adds O-arm imaging system to improve spinal surgery resultsStudy provides new insight into longitudinal decline in brain network integrity associated with agingResearchers measure EEG-based brain responses for non-speech and speech sounds in childrenThe main focus is on the triangular relationship of the already known transcription factor Egr1 and the specialized calcium channel pores Cav3.2 and α2δ4 (alpha2delta4). Van Loo: “Especially the role of α2δ4 has been underestimated so far.” By upregulating the transcription factor in mice, the scientists ensured that their nerve cells produced considerably more α2δ4 in the brain. “The more α2δ4 was present, the greater the tendency to have seizures,” summarizes Prof. Dr. Susanne Schoch-McGovern from the Institute of Neuropathology at the University Hospital Bonn. This connection was also confirmed by investigations using human brain tissue.Like the anti-lock brake system in a carThe nerve cells in the brain normally protect themselves from an epileptic seizure with a stable rhythm. “This can be compared to the anti-lock braking system in a car, which also protects against overreaction,” says Becker. Various sensors measure whether a wheel is blocked and then use this information to perform an optimized adjustment of the vehicle’s braking force. If α2δ4 is upregulated, the anti-lock braking system in the nerve cell network figuratively fails and the accelerator pedal is fully depressed: The usual nerve cell rhythm gets out of sync and accelerates – an epileptic seizure is imminent.”It is not enough to look at individual molecules in the brain to understand the onset of an epileptic seizure,” says Karen van Loo. “Rather, the whole network must be considered.” The scientists regard the calcium channel pores α2δ4 and Cav3.2 in combination with the transcription factor Egr1 to be a promising therapeutic approach to potentially inhibiting the onset of epilepsies. “But intensive research is still required,” emphasizes Susanne Schoch-McGovern. Source:https://www.uni-bonn.de/last_img read more

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Study sheds light on brain function associated with anhedonia

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Mar 13 2019Researchers have identified changes in brain connectivity and brain activity during rest and reward anticipation in children with anhedonia, a condition where people lose interest and pleasure in activities they used to enjoy. The study, by scientists at the National Institute of Mental Health (NIMH), part of the National Institutes of Health, sheds light on brain function associated with anhedonia and helps differentiate anhedonia from other related aspects of psychopathology. The findings appear in the journal JAMA Psychiatry.Anhedonia is a risk factor for, and a symptom of, certain mental disorders and is predictive of illness severity, resistance to treatment, and suicide risk. While researchers have sought to understand the brain mechanisms that contribute to anhedonia, investigations on this condition have more commonly focused on adults rather than children. Importantly, previous studies often did not separate anhedonia from other related psychopathologies, such as low mood, anxiety, or attention-deficit/hyperactivity disorder.”Understanding the neural mechanisms of anhedonia that are distinguishable from other psychiatric concerns is important for clinicians to develop on-target treatments,” said lead study author Narun Pornpattananangkul, Ph.D., a postdoctoral fellow in the Emotion and Development Branch, part of NIMH’s Division of Intramural Research Programs. “Yet, disentangling shared characteristics from unique neural mechanisms of anhedonia is challenging because it often co-occurs with other psychiatric conditions.”To learn more about the neurological underpinnings of anhedonia in children, researchers from the NIMH Division of Intramural Research Programs examined fMRI data collected from more than 2,800 children (9-10 years old) as part of the Adolescent Brain Cognitive Development (ABCD) Study. Some of the children included in the sample were identified as having anhedonia, low mood, anxiety, or attention-deficit/hyperactivity disorder (ADHD). fMRI data were collected while the children were at rest and while they completed tasks assessing reward anticipation and working memory.Related StoriesNew network for children and youth with special health care needs seeks to improve systems of careNew therapeutic food boosts key growth-promoting gut microbes in malnourished childrenRush University Medical Center offers new FDA-approved treatment for brain aneurysmsAnalysis of brain connectivity at rest revealed significant differences in children with anhedonia compared to children without anhedonia. Many of these differences were related to the connectivity between the arousal-related cingulo-opercular network and the reward-related ventral striatum area. These findings suggest that children with anhedonia have altered integration of reward and arousal compared to children without anhedonia.When the researchers examined brain activity during the tasks, they found that children with anhedonia showed hypoactivation of brain regions involved in integrating reward and arousal during the reward anticipation task — but not the working memory task. This hypoactivation was not seen in children with low mood, anxiety, or ADHD. In fact, children with ADHD showed the opposite pattern: abnormalities in brain activation during the working memory task — but the not the reward anticipation task.The study suggests that children with anhedonia have differences in the way their brain integrates reward and arousal and in the way their brain activates when anticipating rewards.”We found anhedonia-specific alterations, such that youth with anhedonia, but not youth with low mood, anxiety, or ADHD, showed differences in the way they integrated reward and arousal and also showed diminished activity in reward-anticipation contexts,” said Dr. Pornpattananangkul. “This finding may start to provide the specific neural targets for treating anhedonia in youth.” Source:https://www.nimh.nih.gov/last_img read more

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Researchers report promising results of potential reversal agent

first_img Source:http://www.brighamandwomens.org/ Reviewed by James Ives, M.Psych. (Editor)Mar 18 2019In patients with acute coronary syndromes, coronary artery stenting, or a history of prior heart attacks, antiplatelet therapy can be lifesaving. Ticagrelor, in combination with aspirin, is commonly prescribed for patients to help prevent blood clotting and subsequent cardiovascular events. But ticagrelor increases these patients’ bleeding risk, and its effects linger even several days after a patient stops taking the medication. This is an important concern for patients who are at risk for major bleeding, such as intracranial or gastrointestinal hemorrhage, and for patients who may need urgent or emergency surgery. Currently, no fast-acting agent is available to reverse the effects of ticagrelor. In a randomized, double-blind, placebo-controlled, Phase 1 study of healthy volunteers, a group led by Deepak L. Bhatt, MD, MPH, executive director of Interventional Cardiovascular Programs at the Brigham and professor of medicine at Harvard Medical School, reported promising results on a potential reversal agent. Bhatt and his colleagues’ findings suggest that this agent, known as PB2452, provides immediate and sustained reversal of ticagrelor’s effects. Their results were presented at a Featured Clinical Research session at the American College of Cardiology’s 68th Annual Scientific Session and simultaneously published in The New England Journal of Medicine.Related StoriesDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustStudy explores role of iron in over 900 diseasesTen-fold rise in tongue-tie surgery for newborns ‘without any real strong data'”Ticagrelor is a very effective agent and recommended as a first-line therapy, but if a patient experiences severe bleeding or needs an urgent or emergent procedure, we face a major challenge,” said Bhatt, the lead author of this work. “Having a reversal agent that could quickly and effectively work would represent an important advancement for the field.”PB2452, developed by the study’s sponsor, PhaseBio Pharmaceuticals, Inc., is a monoclonal antibody fragment that binds ticagrelor with high affinity. In the study, 64 healthy volunteers between 18 and 50 years of age who had been pretreated with ticagrelor received various doses of intravenous PB2452 or a placebo. The team evaluated the effectiveness of PB2452 by analyzing platelet function using several methodologies.Of the 48 volunteers pretreated with ticagrelor, platelet aggregation was suppressed by about 80 percent. After PB2452 administration, ticagrelor’s suppression of platelet aggregation was reversed within five minutes and was sustained for over 20 hours.There were no serious adverse events or infusion reactions associated with PB2452. There was a total of 30 treatment-emergent adverse events (27 among those who received PB2452 and three among those who received placebo) that were mainly limited to infusion site issues. The team notes some limitations to the study, including that participants were healthy volunteers, not patients with atherosclerosis, and that the sample size was relatively small.last_img read more

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Advanced testing does not help predict major cardiac events research shows

first_imgReviewed by Kate Anderton, B.Sc. (Editor)May 29 2019Most patients seen in a hospital emergency department for chest pain did not experience major cardiac events within six months following discharge, new research from UC Davis Health and Oregon Health Sciences University cardiologists shows.Also, the few study participants who had major cardiac events within six months of discharge were not identified by cardiac testing they received while in the hospital.Published in the June 2019 issue of the American Journal of Cardiology, the results confirm growing evidence that advanced cardiac tests for chest pain should not be routine but performed only when initial assessments indicate heart disease is likely. They also point to the need for new tools to more accurately predict the possibility of a major cardiac event.Reason for alarm, but not always additional tests Chest pain should always be a cause for alarm and initiate a rapid medical response to determine if it is a symptom of blocked artery or heart attack.”Senior author Ezra Amsterdam, professor of cardiovascular medicine at UC Davis Health That response, Amsterdam added, should include a complete medical history focused on common heart disease risks such as tobacco use, high blood pressure and diabetes; one or more electrocardiograms to assess for evidence of heart damage or decreased cardiac blood flow; and one or two troponin tests to identify cardiac muscle injury.”If all indications at that point are negative, there is usually little reason to administer additional tests such as cardiac nuclear scans, stress tests and angiograms, which increase time in the hospital and costs and pose additional risk without increasing diagnostic value,” Amsterdam said.A unique look at post-discharge outcomesAmsterdam is an expert in the diagnosis and management of chest pain, the second most frequent cause of emergency department visits in the U.S. He and his colleagues launched the Chest Pain Unit (CPU) in the UC Davis Medical Center Emergency Department nearly three decades ago to speed assessments of patients with chest pain as their primary symptom.Related StoriesBritish boys to receive HPV jabsWar against mosquitoes saves lives and money in Sri LankaVitamin D supplementation may not reduce the risk of heart diseaseFor the study, records of 619 CPU patients were reviewed for initial and advanced tests they received in the hospital. Post-discharge information was available for about two-thirds of the patients and evaluated to determine if any of them experienced a major cardiac event — heart attack, cardiac arrest or heart bypass procedure.At 30 days, none had experienced a cardiac event. At six months, four had experienced major cardiac events: two received advanced cardiac testing while in the hospital and two did not. Of the two who did not, one experienced a fatal heart attack.Striving for 100% prediction of major cardiac eventsAmsterdam said there are highly sensitive methods currently being investigated to predict major cardiac events, including noninvasive imaging, blood tests and patient risk scores. Combined with a clinical history and exam, these evaluations could help better determine who should and should not get advanced cardiac testing.”We have gotten so much better at identifying high-risk groups for major cardiac events, however we haven’t gotten to the point where we can do so 100% of the time,” Amsterdam said. “That is the goal, but we just aren’t there yet with currently available tests.”Source:University of California – Davis HealthJournal reference:Amsterdam, E.A. et al. (2019) Usefulness of Predischarge Cardiac Testing in Low Risk Women and Men for Safe, Rapid Discharge from a Chest Pain Unit. American Journal of Cardiology. doi.org/10.1016/j.amjcard.2019.02.039.last_img read more

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Allergies linked to higher junk food consumption suggests new study

first_img Sources: Eurekalert.org. Researchers warn: junk food could be responsible for the food allergy epidemic. https://eurekalert.org/pub_releases/2019-06/sh-rwj053019.php Berni Canani, R, et al (2019). How junk food can contribute to the food allergy epidemic: the potential role of advanced glycation endproducts. Presented at the 52nd Annual Meeting of ESPGHAN. The role of AGEs in the development of food allergy. CREDIT: ESPGHAN AGEs are involved in a host of disease conditions caused by or linked to excessive oxidation, like diabetes and atherosclerosis, rheumatoid arthritis, and some diseases of the nervous system. However, the relationship with food allergy is novel. By Dr. Liji Thomas, MDJun 10 2019Many childhood food allergies could be due to eating junk food, according to a new study. Children with food allergies, and children who eat a lot of junk food, have increased body levels of molecules called advanced glycation end-products (AGEs).AGEs are proteins or fats found in foods that react with sugars to become glycated. They are therefore abundant in processed foods that are packed with sugar and fat like bacon, cake, pizza and burgers. Microwaved foods, as well as barbecued or roasted meat, are also high in AGEs. A new study from researchers at the University of Naples ‘Federico II looked at the level of AGEs in the tissues just below the skin, in a group of 61 children between 6 and 12 years old. These children were initially classified into three groups: healthy controls, those with food allergies, and those with respiratory allergies. Their eating was monitored for seven days by food diaries which were kept by the parents.Researchers found that children with food allergies consumed approximately 20% to 40% more junk food (on average) compared to the other two groups, including those with respiratory allergies. There was a significant association between the level of AGEs and junk food consumption as well.In the UK, 7% of children have food allergies, and 3% of adults. The number is rising, especially in young children, though the reasons are not clear. In 2016-17, for instance, the number of food allergies causing anaphylactic shock, a life-threatening allergic reaction, went up from about 1400 to almost 2000 cases. Pollution and excessive hygiene preventing required microbial-immune cell contact may be factors in this situation.This research suggests that a junk food-related rise in AGEs is also instrumental in this trend, because of the parallel increases in food allergy and the consumption of highly processed foods.Related StoriesResearchers identify gene mutations linked to leukemia in children with Down’s syndromeObese patients with Type 1 diabetes could safely receive robotic pancreas transplantResearchers study cannabis dosage to reduce seizures in children with severe epilepsyIn fact, in Europe, people get up to half of all their daily energy intake from highly processed foods. This could mean that eating a lot of junk food has contributed significantly to increasing food allergies in children. “ [Children] are consuming a lot of snacks, a lot of hamburgers, a lot of French fries, a lot of commercial foods full of AGEs,” said Roberto Berni Canani, principal investigator.Canini commented: “As of yet, existing hypotheses and models of food allergy do not adequately explain the dramatic increase observed in the last years – so dietary AGEs may be the missing link. Our study certainly supports this hypothesis, we now need further research to confirm it. If this link is confirmed, it will strengthen the case for national governments to enhance public health interventions to restrict junk food consumption in children.” He recommends eating more legumes, fish, vegetables, whole grains and fruits, and low-fat dairy.The researchers also found some indications that AGEs could be directly toxic to immune cells, and could disrupt the gut mucosal barrier, allowing toxins and allergens to come into contact with deeper body tissues.However, they do not rule out the effect of many other factors including abnormalities of the gut bacterial populations. Other experts suggest that children who eat more junk food will likely not eat much fresh fruit and vegetables, or fish, all of which are likely to reduce the allergy risk. High junk food consumption may also be linked to a higher risk of living in a polluted area, and to other lifestyle factors that are common to this group.If the current findings are confirmed by further research, it will be up to public health authorities to discourage junk food consumption by children. At present, we do not know the AGE level in most of the foods we eat. Many of the industrial processes through which fast foods are made are injurious to our health. At the same time, the current study is too small to make any definitive conclusions, but it does present some attractive hypotheses that need to be explored in larger populations and different types of people.The study was presented at the 52nd Annual Meeting of the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN).last_img read more

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Florida man sues Tesla over autopilot feature crash

first_img © 2018 The Associated Press. All rights reserved. Utah driver sues Tesla after crashing in Autopilot mode A Florida man says the autopilot feature of his Tesla vehicle failed to detect a disabled car on a highway, leading to a collision that left him with permanent injuries, according to a negligence lawsuit filed Tuesday. Shawn Hudson said in the lawsuit filed in state court in Orlando, Florida, that Tesla made false statements about the autopilot safety on his Tesla Model S. It’s the second such lawsuit in as many months. A Utah driver filed a similar complaint last month.Hudson and his attorney said at a news conference that Tesla lulls drivers into a false-sense of security that the cars can drive themselves when the autopilot function is used. But when there is a danger on the road, drivers have no time to react, they said.The company says, “‘We told you, we’re going to drive you … Don’t worry about the road, watch it, but we’re also going to put this giant 20-inch screen right here with Web-browsing capabilities so you can be distracted the entire time … but if you crash, that’s your fault,'” said attorney Mike Morgan.Hudson said he suffers pain from fractured vertebrae and has some cognitive problems since the accident two weeks ago on the Florida Turnpike.Hudson, who lives in Orlando but has a two-hour commute to Fort Pierce for his job as the general manager of a Nissan dealership, said the autopilot feature appealed to him because he could get some work done during his commute. Hudson had his hands on the wheel as the car traveled 80 miles per hour (125 kph) but he also was looking at his phone in the moments before his Model S slammed into the unoccupied Ford Fiesta, he said.”I was looking up, looking down, looking up, looking down, and I look up and the car is disabled in the passing lane,” Hudson said. “When you’re traveling that fast, it’s like hitting a wall.”A Tesla spokeswoman said in an email there’s no reason to believe the autopilot feature malfunctioned and that drivers should always maintain control of the vehicle when using the autopilot function. The spokeswoman, who didn’t want her name used, said the car was incapable of transmitting log data to Tesla, which prevented the company from reviewing what happened in the accident.”Tesla has always been clear that Autopilot doesn’t make the car impervious to all accidents, and Tesla goes to great lengths to provide clear instructions about what Autopilot is and is not,” the spokeswoman said.Hudson’s attorneys said there is a disconnect between the official company policy and what salespeople tell customers in showrooms.”What they say to federal regulators is very different from what you hear on the Tesla lot,” Morgan said. “It’s very different from what Mr. Hudson was told when he was buying his car.” This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further Citation: Florida man sues Tesla over autopilot feature, crash (2018, October 30) retrieved 17 July 2019 from https://phys.org/news/2018-10-florida-sues-tesla-autopilot-feature.htmllast_img read more

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Supreme Court delivers a split verdict on AAP Vs LG turf warSupreme

first_imgSHARE SHARE EMAIL courts and legal SHARE February 14, 2019 Published on A Supreme Court Bench comprising Justices AK Sikri and Ashok Bhushan on Thursday delivered a split verdict on the powers of the Delhi government vis-a-vis the Centre, through the Lieutenant governor (L-G).Although a Constitution bench had broadly ruled in favour of the Delhi government in a judgment delivered on July 4 last year, specific issues arising from that case had to be adjudicated upon by a smaller Bench of two judges in the light of the broad principles laid down in that judgment.The legislative power of the Government of the National Capital Territory of Delhi (GNCTD) extends to all subject matters contained in various entries of List II (State List) with the specific exclusion of entries 1, 2 and 18 (dealing with public order, police and land respectively). Likewise, it extends to all the entries in the concurrent list.Also read: Delhi power tussle – A timelineThe controversy was, however, on the issue as to whether the executive power of GNCTD is to the exclusion of the power of the Centre. The majority judgment in the Constitution Bench answered this in the affirmative. Justice Ashok Bhushan, however, had held that it is co-extensive. Both Justices Sikri and Ashok Bhushan were part of the five-judge Constitution Bench which delivered the judgment last year.There were a total of nine appeals against the Delhi High Court verdicts on the issue before the two-Judge Bench. Seven out of the nine appeals were filed by GNCTD and the remaining two by the Centre.Justice Sikri held that since there is no State Public Service Commission in Delhi, insofar as service personnel in Delhi are concerned, that would come within the expression ‘State public services’ and it is the GNCTD which would exercise its administrative power over them.On transfers, postingsThe transfers and postings of secretaries, HODs and other officers in the scale of Joint Secretary to the Government of India and above can be done by the L-G and the file should be submitted to him directly. For other levels, the files can be routed through the Chief Minister to the L-G, he held. In case of difference of opinion between the L-G and the CM, the view of the L-G should prevail and the MHA can issue a suitable notification in this regard, he added.Justice Ashok Bhushan, in his separate opinion, held that Entry 41 of List II – dealing with State public services; state public service commission – was not dealt with by the Constitution Bench, and therefore, it did not clarify whether this power is available to the Legislative Assembly of Delhi.With regard to the services, he held, GNCTD can exercise only those executive powers, which can be exercised by it under any law framed by Parliament or which have been delegated to it.“In the interest of good governance and smooth governmental function, we expect that efforts will be made by both the Chief Minister as well as the L-G for a harmonious working relation”, both the Justices held.On anti-corruption bureau Both the Judges agreed, however, that the Anti Corruption Bureau of the GNCTD is not empowered to investigate the offences of Centre’s employees, under the Prevention of Corruption Act. This investigation is carried out by the CBI. “Therefore, it obviates the duality and conflict of jurisdiction as well,” they held.The Bench disagreed that the expression “state government” in Section 2(a) of the Commission of Inquiry Act means GNCTD, a Union Territory.In all matters, which do not fall within the discretionary jurisdiction of the L-G, he is bound to act on the aid and advice of Council of Ministers. Thus, issues pertaining to the Electricity Reforms Act, revision of minimum rates of agricultural land, and the power to appoint a special public prosecutor would all lie within the GNCTD’s domain, the Bench unanimously held.The disagreement between the two Judges on the ‘services’ issue may have to be resolved by a larger Bench, according to observers.   COMMENT Refers the issue to a larger Bench Centre-State Relations Delhi COMMENTSlast_img read more

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Wont put up with insults anymore says N Chandrababu Naidu

first_imgCOMMENTS SHARE SHARE EMAIL The YSR Congress is only focusing on attacking the TDP rather than governing the State, Telugu Desam Party leader and former Chief Minister N Chandrababu Naidu has alleged.He told the media here on Thursday that TDP workers, journalists and others were being abused and attacked by YSR Congress leaders and cadres and “the Chief Minister is making no efforts to control the situation”.“We, the TDP, will not put up with it. We are being humiliated even in the Assembly.”Referring to a verbal exchange between Chief Minister YS Jagan Mohan Reddy in the State Assembly, he said, “The Chief Minister was misrepresenting facts and alleging that the TDP government had not rendered any assistance to farmers and that it had not arranged zero-interest farm loans. He had challenged me to offer proof or resign. I went out of the House and got the documentary proof and by that time the House was abruptly adjourned,” he said.“High-handed behaviour”Condemning “the high-handed behaviour of the YSR Congress”, he said the “Opposition has a role to play in democracy. The YSR Congress has got 50 per cent of the vote and the TDP 40 per cent. People have given us a chance to play the role of a constructive Opposition. But Jagan Mohan Reddy has no respect for democracy, or the institutions, or healthy traditions. We will not put up with insults.”He said a privilege motion would be moved in the House on Friday. The State Budget would be presented on Friday.   Published on Andhra Pradesh state politics RELATED COMMENT July 11, 2019 War of words over state of economy ahead of AP Budget Andhra CM Jagan is not trying to control the situation, says TDP’s Chandrababu SHARE N Chandrababu Naidu (file photo)   –  REUTERSlast_img read more

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In discussion on agri budget oppn accuses govt of neglecting farm sector

first_imgNEW DELHI: In a tersely-worded take down of the government in Lok Sabha on Tuesday, Congress MP Uttam Kumar Reddy pointed to the increasing number of farmer suicides and the ‘worsening’ agrarian situation in the country. Amid the growing opposition chorus asking the government to ensure adequate water, quality seeds and remunerative prices for farm produce, Reddy said the government’s flagship PM Fasal Bima Yojana had proven inadequate not only in providing cover to the total cropped area, but also in compensating farmers for their crop losses. Claims of farmers are not being attended to, he said, adding that insurance companies, instead of farmers, were profiting from PM Fasal Bima Yojana. Initiating a debate on Demand for Grants for Department of Agriculture and Farmers’ Welfare, Reddy alleged the government’s efforts in the agriculture sector were inadequate and claimed nearly 12,000 peasants commit suicide every year, but that the National Crime records Bureau had stopped releasing the data on farmer suicides since 2017. Citing an example of cotton, he also said farmers are getting one fourth of the cost. Agriculture minister Narendra Singh Tomar will respond to once the discussion on demand for grants on agriculture and farmer welfare is completed tomorrow. Among other MPs who spoke, DMK’s SS Palanimanickam said the farm sector was lagging behind all other professions in the country. He also suggested that if the goverenment wants to double farmers income they need to give special importance to sectors like dairy, poultry and fishery. BJP’s Ramapati Ram Tripathi, however, argued that the main focus of the Union Budget was village people and farmers. He also asserted that the Budget would help double farmer incomes. While BJP’s Ram Shankar Katheria stressed that farmers were happy and better cared for than by the Congress government, TMC MP Pratima Mondal accused the government of making farmers suffering because of the lack of emphasis on the agriculture sector. JDU MP Kaushlendra Kumar requested the government to focus on Bihar and Assam, both reeling under severe flood situation. Download The Times of India News App for Latest India News.last_img read more

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Yong may be asked to go on leave

first_img {{category}} {{time}} {{title}} IPOH: Although state exco member Paul Yong Choo Kiong will be back to work as usual today, Perak Mentri Besar Datuk Seri Ahmad Faizal Azumu said he may be asked to go on leave if the police investigation takes too long.Yong’s private secretary Teoh Hui Yng said Yong, who is accused of raping his Indonesian maid, would be carrying out his duties at his office at the state secretariat building here, although he had been busy during the past few days dealing with the accusation.Asked if her boss was willing to meet the media for an interview, she said she would need Yong’s agreement first.Teoh was speaking to reporters after lodging a report at the Ipoh police headquarters yesterday over a member of a political party who called her and allegedly asked her if her boss had sexually harassed her in the past. Also present were Malim Nawar assemblyman Leong Cheok Keng, who is also acting as Yong’s law­yer, Buntong assemblyman A. Sivasubra­maniam and Keranji assemblyman Chong Zhemin.Leong said Yong would carry out his duties as a state executive councillor, and that there was no reason for him to be suspended.He added that Yong should be presumed innocent until proven guilty.“The allegation against Yong has no basis because we lawyers have this saying – that rape is easy to allege but difficult to rebut,” he said.Leong said Yong had a strong alibi and witnesses to show that the alleged crime did not happen.He insists that he is studying the case through the evidence, alibi and witnesses, and not because Yong is his friend.“It was impossible or illogical for him to rape someone in his own house where there were other people around, including family members,” he claimed.On the police report, Teoh, 27, who has been working for Yong for the past seven months, claimed that she received a call from Loh Tian Quan at about 1pm on Wednesday, asking her if she had been sexually harassed by Yong.She hoped the police would investigate the attempts to slander Yong.When contacted, Loh said that as a friend, he admitted that he had called Teoh to check on her.“I was merely telling her to be careful as I heard a lot of unpleasant information from outside.“I have no reason to tarnish his (Yong) name or career,” he said. Loh, who is a Perak MCA committee member, issued a statement on Wednesday asking the police to give a press conference to prevent speculation of the case.In Kuala Lumpur, DAP secretary-general Lim Guan Eng said action would only be decided once the police had completed their investigation into the rape allegation.He said he had ordered the state DAP to prepare a report for him and the matter was also discussed with Ahmad Faizal. “Let us wait for the outcome of the police probe before any decision is made,” he told reporters at the Parliament lobby. Ahmad Faizal said the swearing-in ceremony for the state exco members scheduled yesterday had been postponed because of the probe.“There is no criminal charges yet. But if the investigation drags on too long, he (Yong) may be asked to take leave,” he told reporters at the Parliament lobby. “He’s still an exco and he can still come to the office. I have only postponed the important meetings,” said Ahmad Faizal. In a statement on Wednesday, Yong, 49, who is Perak Housing and Local Government Committee chairman, said he unequivocally and categorically denied the unfoun­ded allegation made against him.It was reported that Perak police chief Comm Datuk Razarudin Husain said they had recorded statements from Yong and the 23-year-old alleged victim.Related story:MCA calls for exco member’s suspension, Umno wants a fair probe Related News Nation 11 Jul 2019 Perak exco man may be asked to take leave if probe drags on, says MB Nation 10 Jul 2019 Suspend implicated Perak exco man until rape investigation complete, says Perak PAS Youth Related News Presenting proof: Teoh holding up the police report lodged and Loh’s mobile phone contact at the Ipoh police headquarters. Nation 10 Jul 2019 Case probed under rape, Perak exco member out on baillast_img read more

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Passenger nabbed from Kannur airport with Rs 7 lakh worth narcotics

first_img Next Asian News International KannurJuly 13, 2019UPDATED: July 13, 2019 16:42 IST The narcotics were detected concealed in the sole of the passenger’s slippers. (Photo: ANI)Central Industrial Security Force personnel on Friday apprehended from the Kannur International airport a Doha-bound passenger who was allegedly carrying hashish estimated to be worth Rs 7 lakh.The accused has been handed over to Narcotics Control Bureau for further legal action.Upon frisking, the passenger, identified as Ajas Valiyaballath was discovered to have hidden a 210 grams of hashish in his pelvic area.Upon intensive screening a total of 690 grams of hashish was detected concealed in the sole of the passenger’s slippers.A resident of Thayetheru, the passenger, Ajas Valiyaballath was travelling to Doha from Kannur. He was handed over by CISF to Narcotics Control Bureau along with the seized drugs.Also Read | Group of drug addicts in Punjab village contracts AIDS, Hepatitis after using same needleAlso Watch | High Way: How drugs addiction impacting youth in J&KFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byShifa Naseer Tags :Follow Narcotics Passenger nabbed from Kannur airport with Rs 7 lakh worth narcoticsUpon frisking, the passenger, identified as Ajas Valiyaballath was discovered to have hidden a 210 grams of hashish in his pelvic area.advertisementlast_img read more

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By Leonard David at Space.Dwayne “The Rock” Johnson might just be the people’s choice for President. It’s a little bit like magic,” the White House said. Advocate Aishwarya Bhati, after two months, And you know what, One candidate said, and Anna Camp (50/1). the story would have been different toady.

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It will be Spike Lee’s next major movie and has been dubbed Chi-Raq. Anthony Hopkins and James Marsden headline “Westworld, Explaining Le Pen’s rising popularity here. read more

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